UConn School of Medicine

Providing educational opportunities for those pursuing careers in the patient care professions, education, public health, biomedical and/or behavioral sciences.
New teaching center for team-based learning.
Helping health care professionals maintain their competence through continuing education programs.
Developing, demonstrating, and delivering health care services based on effectiveness, efficiency, and the application of the latest advances in clinical, translational and health care research.
Advancing knowledge through basic, biomedical, clinical, translational, behavioral, and social research.

Advancing knowledge through basic, biomedical, clinical, translational, behavioral, and social research.
New teaching center for team-based learning.
Developing, demonstrating, and delivering health care services based on effectiveness, efficiency, and the application of the latest advances in clinical, translational and health care research.
Providing educational opportunities for those pursuing careers in the patient care professions, education, public health, biomedical and/or behavioral sciences.
Helping health care professionals maintain their competence through continuing education programs.

World’s First Gene Therapy for Glycogen Storage Disease Produces Remarkable Results

The clinical trial originally set out to simply test the safety and dosage of the gene therapy for three patients with GSD Type Ia. The dramatic improvement in their lives was unexpected.

School of Medicine Receives Full Accreditation

The Liaison Committee on Medical Education (LCME) made the decision to grant UConn School of Medicine full accreditation of its medical education program for an eight-year term, the maximum term allowable. The LCME is recognized by the U.S. Department of Education as the reliable authority for the accreditation of medical education programs.

UConn School of Medicine's Lakshmi Nair, Ph.D., accepting her 2019 GWIMS award presented by Liisa Kuhn, Ph.D.

Outstanding Women in Medicine and Science Honored

The Group on Women in Medicine and Science (GWIMS) at UConn Health held its annual symposium May 6 to honor outstanding women faculty, and other standout female graduate, medical and dental students.

World’s First Gene Therapy for Glycogen Storage Disease Produces Remarkable Results

The clinical trial originally set out to simply test the safety and dosage of the gene therapy for three patients with GSD Type Ia. The dramatic improvement in their lives was unexpected.

School of Medicine Receives Full Accreditation

Outstanding Women in Medicine and Science Honored

The Group on Women in Medicine and Science (GWIMS) at UConn Health held its annual symposium May 6 to honor outstanding women faculty, and other standout female graduate, medical and dental students.

Jan 26 MBB Seminar: David Jeruzalmi12:00pm

MBB Seminar: David Jeruzalmi

Tuesday, January 26th, 2021

12:00 PM - 01:00 PM

UConn Health
WebEx

"Mechanisms of Opening and Closing the Bacterial Replicative Helicase"

Contact Information: Shanaz Mohamad - 860-679-2885 - mohamad@uchc.edu
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Jan 27 Neuroscience Journal Club - Miles12:00pm

Neuroscience Journal Club - Miles

Wednesday, January 27th, 2021

12:00 PM - 01:00 PM

Other
Blackboard Link

Neuroscience Journal Club

Presenter:
Christina Miles
Smith Lab

Paper to be presented:
Jiwei Yao, Qianwei Li, Xianping Li, Han Qin, et al. Simultaneous Measurement of Neuronal Activity in the Pontine Micturition Center and Cystometry in Freely Moving Mice. Frontiers in Neuroscience PMID: 31293380

Link to paper: https://pubmed.ncbi.nlm.nih.gov/31293380/

Contact Information: David Martinellii, davidmartinelli@uchc.edu & Rosa Guzzo, guzzo@uchc.edu
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Jan 28 Neuroscience Virtual Seminar Series - Yan11:00am

Neuroscience Virtual Seminar Series - Yan

Thursday, January 28th, 2021

11:00 AM - 12:00 PM

Other
Virtual

Sponsored by the Kim Family Fund

Title: "C. elegans as a Window into Glial Development"

Presenter:
Dong Yan, PhD
Asst. Professor, Dept. of Molecular Genetics & Microbiology Duke University, Durham, NC

Relevant citations:
https://pubmed.ncbi.nlm.nih.gov/33370778/ AND
https://pubmed.ncbi.nlm.nih.gov/33211005/

Host: Bojun Chen, PhD, bochen@uchc.edu

Contact Information: Jody Gridley, gridley@uchc.edu
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Jan 28 CCAM Seminar Series - Ditlev12:00pm

CCAM Seminar Series - Ditlev

Thursday, January 28th, 2021

12:00 PM - 01:00 PM

UConn Health
Virtual

CCAM Seminar Series
Time: 12:00 pm
Host: Dr. Bruce Mayer
Speaker: Jonathon Ditlev, Ph.D., Assistant Professor, Department of Biochemistry, University of Toronto, Scientist, Molecular Medicine Program, The Hospital for Sick Children
Title: “Phase separation: a paradigm shift for understanding the formation and function of T cell signaling clusters”
Abstract: In T cells, activation of many cell surface receptors induces the reorganization of downstream signaling molecules into submicrometer-sized clusters. Upon binding of the T cell receptor to an agonist on an antigen presenting cell, a series of phosphorylation events promotes clustering of the membrane-localized adaptor protein LAT. Subsequently, LAT clusters are moved across the membrane of the T cell by two different concentric actin cytoskeletal networks. This dynamic process is required for proper T cell signaling. However, the mechanism by which LAT clusters form, the functional consequences of clustering, and the mechanism by which clusters are moved by two distinct actin cytoskeletal networks were unclear. The signaling pathway, beginning with the T cell receptor and ending with actin assembly, was reconstituted on model membranes. Triggering of T cell receptor phosphorylation resulted in the formation of membrane-localized liquid-like phase separated clusters composed of signaling molecules that promoted signaling outputs in biochemical reconstitutions and human Jurkat T cells. Reconstituted clusters were enriched in kinases but excluded phosphatases, promoted local actin assembly by recruiting actin nucleation machinery, and displayed compositional-dependent interactions with dynamic actomyosin networks. When Nck and its binding partner N-WASP were present in clusters, clusters bound to and moved with dynamic actin filaments. Clusters lacking these components were instead sterically propelled by moving actin filaments. In cells, Nck dissipates from LAT clusters as they are moved across the boundary between the two actin networks. This change in composition likely enables cluster movement by the distinct dynamics of each network to promote T cell signaling. Thus, phase separation of LAT and its binding partners promotes signal propagation from clusters while compositional changes within the clusters enable them to be moved by two distinct actin networks to maintain proper T cell signaling. The principles revealed by these studies likely apply to the numerous two- and three-dimensional phase separated structures that exist within a cell.
Meeting link:
https://uconn-cmr.webex.com/uconn-cmr/j.php?MTID=mac3796f3a0f1ce4e9856ae9bcee21578
Meeting number: 120 463 0186
Password: EJnJ9Y8s6VP
Host key: 583108
More ways to join
Join by video system
Dial 1204630186@uconn-cmr.webex.com
You can also dial 173.243.2.68 and enter your meeting number.
Join by phone
+1-415-655-0002 US Toll
Access code: 120 463 0186

Contact Information: Tiffany; jespersen@uchc.edu
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Feb 3 Neuroscience Journal Club - Ragan12:00pm

Neuroscience Journal Club - Ragan

Wednesday, February 3rd, 2021

12:00 PM - 01:00 PM

Other
Blackboard Link

Neuroscience Journal Club

Presenter: Michal Ragan
Wang Lab

Paper to be presented:
Boxing Li, Benjamin S. Suutari, Simon D. Sun, Zhengyi Luo, et al. Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening,
Cell,Volume 181, Issue 7,2020,Pages 1547-1565.e15,ISSN 0092-8674.

Link to paper: https://www.sciencedirect.com/science/article/pii/S0092867420305754?via%3Dihub

Contact Information: David Martinellii, davidmartinelli@uchc.edu & Rosa Guzzo, guzzo@uchc.edu
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News

World’s First Gene Therapy for Glycogen Storage Disease Produces Remarkable Results

School of Medicine Receives Full Accreditation

Outstanding Women in Medicine and Science Honored

News

World’s First Gene Therapy for Glycogen Storage Disease Produces Remarkable Results

School of Medicine Receives Full Accreditation

Outstanding Women in Medicine and Science Honored

Spotlight

Golda S. Ginsburg, Ph.D.

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