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  1. Jan 26 MBB Seminar: David Jeruzalmi12:00pm

    MBB Seminar: David Jeruzalmi

    Tuesday, January 26th, 2021

    12:00 PM - 01:00 PM

    UConn Health
    WebEx

    "Mechanisms of Opening and Closing the Bacterial Replicative Helicase"

    Contact Information: Shanaz Mohamad - 860-679-2885 - mohamad@uchc.edu

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  2. Jan 27 Neuroscience Journal Club - Miles12:00pm

    Neuroscience Journal Club - Miles

    Wednesday, January 27th, 2021

    12:00 PM - 01:00 PM

    Other
    Blackboard Link

    Neuroscience Journal Club

    Presenter:
    Christina Miles
    Smith Lab

    Paper to be presented:
    Jiwei Yao, Qianwei Li, Xianping Li, Han Qin, et al. Simultaneous Measurement of Neuronal Activity in the Pontine Micturition Center and Cystometry in Freely Moving Mice. Frontiers in Neuroscience PMID: 31293380


    Link to paper: https://pubmed.ncbi.nlm.nih.gov/31293380/

    Contact Information: David Martinellii, davidmartinelli@uchc.edu & Rosa Guzzo, guzzo@uchc.edu

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  3. Jan 28 Neuroscience Virtual Seminar Series - Yan11:00am

    Neuroscience Virtual Seminar Series - Yan

    Thursday, January 28th, 2021

    11:00 AM - 12:00 PM

    Other
    Virtual

    Sponsored by the Kim Family Fund

    Title: "C. elegans as a Window into Glial Development"

    Presenter:
    Dong Yan, PhD
    Asst. Professor, Dept. of Molecular Genetics & Microbiology Duke University, Durham, NC

    Relevant citations:
    https://pubmed.ncbi.nlm.nih.gov/33370778/ AND
    https://pubmed.ncbi.nlm.nih.gov/33211005/

    Host: Bojun Chen, PhD, bochen@uchc.edu

    Contact Information: Jody Gridley, gridley@uchc.edu

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  4. Jan 28 CCAM Seminar Series - Ditlev12:00pm

    CCAM Seminar Series - Ditlev

    Thursday, January 28th, 2021

    12:00 PM - 01:00 PM

    UConn Health
    Virtual

    CCAM Seminar Series
    Time: 12:00 pm
    Host: Dr. Bruce Mayer
    Speaker: Jonathon Ditlev, Ph.D., Assistant Professor, Department of Biochemistry, University of Toronto, Scientist, Molecular Medicine Program, The Hospital for Sick Children
    Title: “Phase separation: a paradigm shift for understanding the formation and function of T cell signaling clusters”
    Abstract: In T cells, activation of many cell surface receptors induces the reorganization of downstream signaling molecules into submicrometer-sized clusters. Upon binding of the T cell receptor to an agonist on an antigen presenting cell, a series of phosphorylation events promotes clustering of the membrane-localized adaptor protein LAT. Subsequently, LAT clusters are moved across the membrane of the T cell by two different concentric actin cytoskeletal networks. This dynamic process is required for proper T cell signaling. However, the mechanism by which LAT clusters form, the functional consequences of clustering, and the mechanism by which clusters are moved by two distinct actin cytoskeletal networks were unclear. The signaling pathway, beginning with the T cell receptor and ending with actin assembly, was reconstituted on model membranes. Triggering of T cell receptor phosphorylation resulted in the formation of membrane-localized liquid-like phase separated clusters composed of signaling molecules that promoted signaling outputs in biochemical reconstitutions and human Jurkat T cells. Reconstituted clusters were enriched in kinases but excluded phosphatases, promoted local actin assembly by recruiting actin nucleation machinery, and displayed compositional-dependent interactions with dynamic actomyosin networks. When Nck and its binding partner N-WASP were present in clusters, clusters bound to and moved with dynamic actin filaments. Clusters lacking these components were instead sterically propelled by moving actin filaments. In cells, Nck dissipates from LAT clusters as they are moved across the boundary between the two actin networks. This change in composition likely enables cluster movement by the distinct dynamics of each network to promote T cell signaling. Thus, phase separation of LAT and its binding partners promotes signal propagation from clusters while compositional changes within the clusters enable them to be moved by two distinct actin networks to maintain proper T cell signaling. The principles revealed by these studies likely apply to the numerous two- and three-dimensional phase separated structures that exist within a cell.
    Meeting link:
    https://uconn-cmr.webex.com/uconn-cmr/j.php?MTID=mac3796f3a0f1ce4e9856ae9bcee21578
    Meeting number: 120 463 0186
    Password: EJnJ9Y8s6VP
    Host key: 583108
    More ways to join
    Join by video system
    Dial 1204630186@uconn-cmr.webex.com
    You can also dial 173.243.2.68 and enter your meeting number.
    Join by phone
    +1-415-655-0002 US Toll
    Access code: 120 463 0186

    Contact Information: Tiffany; jespersen@uchc.edu

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  5. Feb 3 Neuroscience Journal Club - Ragan12:00pm

    Neuroscience Journal Club - Ragan

    Wednesday, February 3rd, 2021

    12:00 PM - 01:00 PM

    Other
    Blackboard Link

    Neuroscience Journal Club

    Presenter: Michal Ragan
    Wang Lab

    Paper to be presented:
    Boxing Li, Benjamin S. Suutari, Simon D. Sun, Zhengyi Luo, et al. Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening,
    Cell,Volume 181, Issue 7,2020,Pages 1547-1565.e15,ISSN 0092-8674.

    Link to paper: https://www.sciencedirect.com/science/article/pii/S0092867420305754?via%3Dihub

    Contact Information: David Martinellii, davidmartinelli@uchc.edu & Rosa Guzzo, guzzo@uchc.edu

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