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  • two female uconn health doctors
    Helping health care professionals maintain their competence through continuing education programs.
  • Patient Tower 2015
    Providing educational opportunities for those pursuing careers in the patient care professions, education, public health, biomedical and/or behavioral sciences.
  • UConn Health Center Learning Equipment
    Advancing knowledge through basic, biomedical, clinical, translational, behavioral, and social research.
  • The School's new circular teaching hall.
    New teaching center for team-based learning.
  • UConn Health First in New England to Offer Robot-Guided Spine Surgery
    Developing, demonstrating, and delivering health care services based on effectiveness, efficiency, and the application of the latest advances in clinical, translational and health care research.

The mission of the UConn School of Medicine is innovation, discovery and education. We train the next generation of medical students, residents, specialty fellows, and clinical practitioners in an environment of exemplary patient care, research, and public service.

Information For:

user icon Prospective Students stethoscope icon Current Students Hospital icon Residents and Fellows medical pprofessional icon Faculty cap icon Alumni and Friends
  • Patient Tower 2015
    Providing educational opportunities for those pursuing careers in the patient care professions, education, public health, biomedical and/or behavioral sciences.
  • two female uconn health doctors
    Helping health care professionals maintain their competence through continuing education programs.
  • UConn Health Center Learning Equipment
    Advancing knowledge through basic, biomedical, clinical, translational, behavioral, and social research.
  • UConn Health First in New England to Offer Robot-Guided Spine Surgery
    Developing, demonstrating, and delivering health care services based on effectiveness, efficiency, and the application of the latest advances in clinical, translational and health care research.
  • The School's new circular teaching hall.
    New teaching center for team-based learning.

The mission of the UConn School of Medicine is innovation, discovery and education. We train the next generation of medical students, residents, specialty fellows, and clinical practitioners in an environment of exemplary patient care, research, and public service.

Information For:

user icon Prospective Students stethoscope icon Current Students Hospital icon Residents and Fellows medical pprofessional icon Faculty cap icon Alumni and Friends

News

Abstract web of connecting lines with lights
CICATS + IRE = Connecticut Convergence Institute
UConn has combined the Connecticut Institute for Clinical and Translational Science and the Institute for Regenerative Engineering to form the Connecticut Convergence Institute for Translation in Regenerative Engineering within the UConn School of Medicine. Read the announcement from Dr. Cato T. Laurencin (director), and Dr. Lakshmi Nair (associate director).

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UConn Health Academic Building
School of Medicine Receives Full Accreditation
The Liaison Committee on Medical Education (LCME) made the decision to grant UConn School of Medicine full accreditation of its medical education program for an eight-year term, the maximum term allowable. The LCME is recognized by the U.S. Department of Education as the reliable authority for the accreditation of medical education programs.

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Annabelle Rodriguez-Oquendo, a UConn Health research, in her lab holding a pipette and smiling for the camera
Seven UConn Researchers Honored by the Connecticut Academy of Science and Engineering
Members of CASE are elected from among the state's leading experts in science, engineering, and technology.

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News

Abstract web of connecting lines with lights
CICATS + IRE = Connecticut Convergence Institute
UConn has combined the Connecticut Institute for Clinical and Translational Science and the Institute for Regenerative Engineering to form the Connecticut Convergence Institute for Translation in Regenerative Engineering within the UConn School of Medicine. Read the announcement from Dr. Cato T. Laurencin (director), and Dr. Lakshmi Nair (associate director).

Read More

UConn Health Academic Building
School of Medicine Receives Full Accreditation
The Liaison Committee on Medical Education (LCME) made the decision to grant UConn School of Medicine full accreditation of its medical education program for an eight-year term, the maximum term allowable. The LCME is recognized by the U.S. Department of Education as the reliable authority for the accreditation of medical education programs.

Read More

Annabelle Rodriguez-Oquendo, a UConn Health research, in her lab holding a pipette and smiling for the camera
Seven UConn Researchers Honored by the Connecticut Academy of Science and Engineering
Members of CASE are elected from among the state's leading experts in science, engineering, and technology.

Read More

Spotlight

Justin Cotney, Ph.D., in his lab

Justin Cotney, Ph.D.

Meet Assistant Professor of Genetics and Molecular Biology, Department of Genetics and Genome Sciences, Justin Cotney, Ph.D.

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Events

  1. Mar 25 MBB WIP: Thomas Bregnard12:00pm
  2. Mar 26 Neuroscience Seminar Series - Wang4:00pm
  3. Mar 27 Neuroscience Journal Club - Xing12:00pm
  4. Mar 27 Cell Biology Seminar - Richard E. Cheney, PhD12:00pm
  5. Mar 28 CCAM Seminar Series - Kim Dodge-Kafka12:00pm

MBB WIP: Thomas Bregnard

Monday, March 25th, 2019

12:00 PM - 01:00 PM

UConn Health
E2036

"Characterization of the sites and mechanism of arsenic binding to the PML protein"

Contact Information: Bridget Clancy-Tenan, 860-679-2108, clancy@uchc.edu

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Neuroscience Seminar Series - Wang

Tuesday, March 26th, 2019

04:00 PM - 05:00 PM

UConn Health
Low Learning Center

Sponsored by the Kim Family Fund

"AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor."

Presenter:
Zhao-Wen Wang, PhD, Professor, Department of Neuroscience, UConn Health, Farmington, CT

Citation:
Chen B, Hujber EJ, Li Y, Jorgensen EM, and Wang ZW. AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor. Nat Commun 2017
https://www.nature.com/articles/s41467-017-01704-z

Contact Information: Jody Gridley, gridley@uchc.edu, 860-679-8787

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Neuroscience Journal Club - Xing

Wednesday, March 27th, 2019

12:00 PM - 01:00 PM

UConn Health
E4036

Neuroscience Journal Club

Jian Xing
Graduate Assistant

Paper to be presented: Levin, E., Leibinger, M., Gobrecht, P., Hilla, A., Andreadaki, A., and Fischer, D. (2019) Muscle LIM Protein Is Expressed in the Injured Adult CNS and Promotes Axon Regeneration Cell Rep. 26, 1021–1032.e6

Link: https://www.sciencedirect.com/science/article/pii/S2211124718319569?via%3Dihub

Contact Information: Jody Gridley, gridley@uchc.edu, 860-679-8787

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Cell Biology Seminar - Richard E. Cheney, PhD

Wednesday, March 27th, 2019

12:00 PM - 01:00 PM

UConn Health
E5036

SPEAKER: Richard E. Cheney, PhD, University of North Carolina at Chapel Hill

TITLE: "Cellular and organismal functions of myosin-X, a filopodial motor protein”

HOST: Dr. Mark Terasaki

Contact Information: Deb Allaire x1034

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CCAM Seminar Series - Kim Dodge-Kafka

Thursday, March 28th, 2019

12:00 PM - 01:00 PM

UConn Health
CGSB, CCAM Conference Room, R1673, 400 Farmington Ave

CCAM Seminar Series
Speaker: Kim Dodge-Kafka, Associate Professor, Department of Cell Biology Calhoun Cardiology Center, UConn Health
Title:
“mAKAP – a master regulator of cardiac hypertrophy”

Abstract:
Cardiac hypertrophy is the primary response of the heart to stress and is defined as an increase in the myocyte cell size in the absence of cellular growth [1]. Key to the development of hypertrophy is an increase in gene transcription that induces pathological remodeling, allowing for changes in ion fluxes, metabolic functions, cell death and interstitial fibrosis [2]. Key studies performed in genetically modified mice have shown that activation of specific transcription factors, namely NFAT, MEF2, GATA4, NF-kB and C-MYC, drives this increase in gene transcription responsible for the pathological cardiac remodeling [2]. Therefore, defining the upstream signals that stimulate transcription factor activation has thus become an intense area of research. Significant work has defined these signaling networks to include the mitogen-activated protein kinase (MAPK), cyclic nucleotide, calcium, hypoxia and phosphoinositide-dependent pathways [3]. However, how these cytosolic signaling enzymes are directed onto the nuclear transcription factor is still unclear. One mechanism that has evolved to play a critical role in defining the specificity of signaling networks is the scaffolding protein [4]. These typically non-enzymatic proteins function to co-localize signaling enzymes into a discrete complex containing their downstream substrates, thereby increasing the speed and efficacy of signaling events while defining substrate specificity. Furthermore, as scaffolds usually bind to enzymes from multiple signaling pathways, they help to integrate multiples upstream signals, thereby providing a combinatorial regulation of signaling events.

In particular, A-Kinase anchoring proteins (AKAPs) have been shown to be important scaffolding proteins in the heart [5]. These proteins are defined by their ability to bind the regulatory subunit of Protein Kinase A (PKA), thereby sequestering the kinase into discrete cellular domains via a specific localization sequence unique for each AKAP. As they also associated with multiple other signaling enzymes such as phosphatases, phosphodiesterases, and other kinases, they incorporate multiple upstream signals to mediate phosphorylation events [5]. The first demonstration of the importance of AKAPs for cardiac physiology utilized a peptide to globally disrupt AKAP/PKA binding. Incubation of this peptide in cardiac myocytes found AKAPs play a role in the -adrenergic stimulation of calcium influx and contraction[6]. Since these original findings, AKAP have been shown to regulate many events such as potassium channel currents, sarcoplasmic calcium cycling, and G-protein coupled signaling [7-9]. Additionally, many AKAPs are involved in the induction of cardiac disease [5]. Once such AKAP is the muscle-selecti

Contact Information: Tiffany x6103

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